Innovation Accelerated

High-performance computing (HPC) is solving the world’s most complex challenges. Speed, scale, and efficiency are essential—AMD delivers all three. Our adaptable, energy-efficient platforms power game-changing compute performance, enabling breakthrough innovations across many industries, from research to finance, healthcare, and beyond.

Performance & Efficiency

AMD delivers the scalable, efficient performance needed to power the world’s most advanced Exascale-class systems — enabling faster insights and new discoveries.

Open Software Environment

AMD offers compilers, libraries, frameworks, and tools required to deploy the largest HPC and AI systems in an open and collaborative environment.

Optimized HPC & AI Workloads

AMD HPC processors, including EPYC and Instinct, feature high core counts and scalable fabrics to optimize AI workloads and accelerate research and innovation.

Applications

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Scientific Research & Academia

Accelerating complex simulations in climate modeling, astrophysics, and quantum mechanics.

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Healthcare & Life Sciences

Enhancing genomics research, drug discovery, and medical imaging, contributing to advancements in personalized medicine.

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Financial Services

Delivering exceptional performance for financial modeling and risk analysis.

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Manufacturing & Engineering

Supporting computational fluid dynamics and predictive maintenance applications.

Addressing the World’s Toughest Challenges

Supercomputers and HPC systems are simulating the complex interactions behind weather, genomics, physics, and beyond. Exascale systems can execute a quintillion operations per second, enabling unprecedented time-to-insight. Explore how AMD solutions are powering these leading-edge systems and propelling innovation like never before.

Supercomputers

AMD processors power many of the world’s leading supercomputers, including the world’s two fastest: El Capitan and Frontier, as well as LUMI, the fastest supercomputer in Europe.

El Capitan 

AMD collaborated with the U.S. Department of Energy, Lawrence Livermore National Laboratory, and HPE to design El Capitan, which is currently the most powerful supercomputer in the world.1

El Capitan is built on AMD Instinct™ MI300A accelerated processing units (APUs), which offer exceptional compute density and efficiency, high-bandwidth memory, and advanced I/O sub systems. It is designed to excel at the most challenging HPC workloads and support AI and ML-based data analysis, enabling large models to run accurately.

Frontier

AMD collaborated with the U.S. Department of Energy, Oak Ridge National Laboratory, and HPE Cray to design the Frontier supercomputer. Featuring optimized 3rd Gen AMD EPYC™ processors and AMD Instinct MI250X accelerators, Frontier was the first supercomputer to officially cross the Exascale barrier with 1.1 exaflops of performance. 

Frontier pushes the boundaries of scientific discovery by dramatically enhancing AI, analytics, and simulation performance—helping scientists pack in more calculations, identify new patterns in data, and get to insights faster.

LUMI

EuroHPC’s LUMI supercomputer is a powerful force for climate research, cancer research, and beyond. LUMI has granted researchers the unique ability to replicate Earth’s ecosystem down to the square kilometer, providing us with the knowledge to adapt to and potentially alter the course of climate change.

LUMI’s AI capabilities enable a neural network program that can detect cancer early and quickly simulate drug efficacy. This enables pathologists to diagnose cancer growth and simulate bespoke patient reactions to various treatments, so patients get the best personalized care as fast as possible.

Portfolio

AMD offers a robust portfolio of processors, accelerators, and software tools designed to meet the demands of modern HPC and supercomputing workloads. Our solutions are engineered for scalability, performance, and efficiency, ensuring that researchers and enterprises can tackle their most demanding computational tasks.

Case Studies

CSIRO

CSIRO's Square Kilometre Array telescope could unlock the secrets of the universe with massive data processing powered by AMD Alveo™ accelerators.

Snowlake

Snowlake’s Yaddle MD delivers supercomputing-like calculations for motion-based drug design on a single AMD Alveo™ U200 card.

Rimac

Leading electric supercar innovator Rimac employs Microsoft Azure VMs with AMD EPYC™ CPUs to enhance testing simulation pace and speed time-to-market.

Shell

Explore how Shell is paving the way for net-zero data centers of the future by deploying 864 immersion-cooled servers powered by dual 4th Gen AMD EPYC™ processors.

Find Solutions

Find a partner offering AMD hardware-based HPC systems.

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Resources

Documentation

Find solution briefs, datasheets, tuning guides, programmer references, and more documentation for the AMD products powering HPC.

Selector and Estimation Tools

Discover the right AMD EPYC processor to help optimize your data center transformation.

Developer Resources

Find the resources you need to develop HPC applications using AMD products.

AMD ROCm™ Docs

Find release documentation, support documentation, and API documentation for the AMD ROCm™ open software development ecosystem.

AMD Infinity Hub

A repository of pre-optimized HPC applications, facilitating accelerated computing solutions.

AMD Instinct Documentation

A collection of comprehensive guides and technical documentation for getting started with Instinct platforms.

ROCm Blogs

Read the latest news about the ROCm features.

Stay Connected

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Footnotes
  1. Source: Top500 supercomputer list June 2025