The Genesis Mission: AMD and the U.S. Department of Energy Partner to Accelerate AI-Driven Scientific Leadership 

The United States government has launched the Genesis Mission to usher in a new era of AI-enabled discovery. This mission recognizes that leadership in artificial intelligence (AI) is not simply a technological priority, it is essential to the nation’s ability to meet the challenges of the 21st century.  AI leadership will accelerate innovation in science, energy, national security, health, manufacturing, and climate resilience.

Lawrence Livermore National Laboratory (LLNL), with El Capitan, the world’s fastest supercomputer¹, and Oak Ridge National lab (ORNL), with Frontier, the first exascale computer, both powered by AMD technology are cornerstones of U.S. leadership for scientific discovery as we enter this new AI era.

Under Genesis, the DOE is mobilizing the full strength of its national laboratories, private industry partners, and the broader  research community to harness AI as a foundational capability for discovery and innovation at scale. At CES 2026, Michael Kratsios, the Director for the White House Office of Science and Technology Policy, highlighted the Genesis Mission as bringing together the unmatched power of national labs, supercomputers and innovative minds to double the scientific productivity and impact for the next decade.

AMD compute engines with AMD  EPYC™ processors and AMD Instinct™ accelerators  continue to power the nation’s supercomputers to deliver exascale leadership performance, memory capabilities, and energy efficiency needed for AI and HPC workloads. AMD GPUs provide rich native support for FP64 precision to enable accuracy essential for scientific workloads. AMD systems will drive convergence of AI and HPC innovation to enable  integration of AI with traditional simulation and modeling workloads, opening new avenues for scientific discovery.

Lux and Discovery: The Foundational AI Infrastructure for Genesis

Building on the  relationship with our national labs and partners, AMD is enabling the deployment of secure, scalable, and energy-efficient AI infrastructure to support Genesis. The DOE, ORNL, AMD, HPE and OCI are collaborating to deliver two of the Nation’s newest leadership AI supercomputers, Lux and Discovery.

These systems are purpose-built to advance Genesis objectives:

• Expanding sovereign U.S. AI compute capability
• Enabling broad scientific access across the national lab ecosystem
• Integrating AI with simulation, data, and experimental science

• Converting research insights into mission impact faster than ever before

Powered by AMD Instinct™ GPUs and AMD EPYC™ CPUs, these platforms embody the Nation’s commitment to pairing world-class performance with open software ecosystems, secure infrastructure, and deep public–private collaboration and co-innovation.

Advancing the American Science Cloud

As AI scales across the Nation’s research ecosystem, accessibility and connected capability become mission imperatives. AMD is working with ORNL to support the emerging American Science Cloud, a national platform designed to extend advanced AI and high-performance computing capability across DOE laboratories, universities, and mission partners.

This cloud-enabled capability enables collaborative science  with access to leadership-class AI, strengthens the foundation of Genesis, and helps ensure the Nation’s best ideas can move quickly from concept to solution.

 A National Collaboration for American Leadership

The Genesis Mission requires aligned strategy, trusted partnership, and execution strength across government, laboratories, industry, and the research community. Top supercomputers, powered by AMD technologies and deep co-innovation, are enabling breakthroughs in areas such as protein science, genomics, cancer detection, materials discovery, and Earth-system intelligence. 

• Frontier: The world’s first exascale supercomputer, has already advanced bio-medical research and clean energy innovation at ORNL
• El Capitan: The world’s fastest supercomputer, is critical to advancing U.S. national security and nuclear science at LLNL
• Discovery and Lux: Advancing AI for science at ORNL to support the Genesis Mission.

AMD is enabling AI-ready leadership computing systems, advancing platforms designed for large-scale foundation and domain models, and helping integrate AI, simulation, and experimental data into unified scientific workflows. AMD is proud to work with the DOE, ORNL, LLNL, and the broader national laboratory system to extend the transformative potential of AI in support of this national effort.

Future Readiness for AI-enabled Discovery

Consistent with the DOE’s commitment to responsible innovation, Genesis prioritizes energy-efficient AI infrastructure. AMD powers many of the world’s most energy-efficient supercomputers and has committed to delivering a new 20× improvement from a 2024 base year in rack-scale AI energy efficiency by 2030².

Looking ahead, AMD is working with DOE and its labs and partners such as IBM, to advance the convergence of AI, high-performance computing, and quantum computing, ensuring that the United States remains prepared for the next frontier of computational science.

Together, we are building the full spectrum AI infrastructure, open software ecosystem, and deep co-innovation relationships to empower American scientists, strengthen national security, drive economic growth, and secure U.S. leadership in AI-enabled discovery for generations to come.

Sources:

1. 2025 list for TOP500 Supercomputers 
2. AMD surpasses 30x25 goal, sets ambitious new 20x efficiency target