Drive your business success with the right technology for all AI workloads

As the pace—and urgency—of AI innovation accelerates, Supermicro and AMD are working together to help you stay ahead. Deploy Supermicro rack-ready servers with AMD EPYC™ processors and AMD Instinct™ GPUs to unleash performance, cost-effectiveness, and scalability for the massive AI workloads of today and tomorrow.

Up to
1.3x Higher

Conquer AI Challenges with GPU Acceleration

Together, Supermicro and AMD offer an open, robust ecosystem and the breakthrough power needed for the AI lifecycle—all with leadership performance and efficiency to meet your unique needs.

AMD EPYC processors can be used for small-scale AI models and workloads where proximity to data matters, while AMD Instinct GPUs shine for large models and dedicated AI deployments demanding very high performance. Compared to the competition, the AMD Instinct MI355X 8x GPU platform offers up to 1.3x higher inference throughput on the Llama 3.1 405B model at FP4 precision.1

Evolve for AI with Ease

Discover how Supermicro H14 servers, powered by 5th Gen AMD EPYC processors and Instinct MI350 Series GPUs, streamline deployments at scale for the largest AI models.

Read the air-cooled 8U MI350 GPU Datasheet
Read the liquid cooled 4U MI355X GPU Datasheet

Level Up Performance with CPU/GPU Integration

Explore how Supermicro H13 systems, powered by AMD Instinct M1300A APUs, combine the power of AMD Instinct GPUs and AMD EPYC processors with shared memory to supercharge your AI initiatives.

Read the APU Datasheet

Note: Test results for white box system; please refer to www.supermicro.com/aplus for Supermicro product/platform information.

Modernize and Make Room for AI

To make the most of IT budgets, many data centers are already pushing the limits of available space, power, or both. Supermicro servers with AMD EPYC processors deliver leadership performance and efficiency to consolidate your core workloads—freeing up space, power, and cooling to support new business-critical AI workloads. 

Replace 100 old servers with 14 new AMD EPYC 9965 CPU-based servers2

Up To 87%

Up to 87% fewer servers

Up To 71%

Up to 71% less power

Up To 67%

Up to 67% lower 3-yr TCO

Help lower cost and TCO with AMD EPYC 99652

Up To 63%

Up to 63% fewer servers

Up To 45%

Up to 45% less power

Up To 44%

Up to 44% lower 3-yr TCO

Note: Test results for white box system; please refer to www.supermicro.com/aplus for Supermicro product/platform information.

Test Drive Supermicro Systems with the Latest AMD CPUs and GPUs

Experience for yourself when you request a trial of Supermicro H14 servers powered by AMD EPYC processors to test-drive your AI workloads.

Request a Trial on JumpStart
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Why Modernize Now? The IDC Perspective

Learn how AI is driving demand for richly configured servers—and why IDC says it’s imperative to adopt a modern technology stack now. 

Read the White Paper

Customer Stories

Lamini

Using Supermicro GPU Servers with the AMD Instinct™ MI300X, Lamini is able to offer LLM tuning at high speed.

Read Case Study

Absolute Hosting

Read the case study about how Supermicro’s 2U systems powered by 2nd and 3rd Gen AMD EPYC™ CPUs enabled the company to drastically reduce its data center footprint.

Read Case Study

Ahrefs

Read how Supermicro’s AMD EPYC™ CPU based servers enabled Ahrefs to improve SEO terms and increase service offerings to its customers.

Read Case Study
AMD Instinct GPU Remote Access Form

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Request Contact from an AMD EPYC™ and Supermicro Sales Expert

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Footnotes
  1. MI350-038: Based on measurements by AMD as of 6/6/2025 of the text-generated throughput for LLaMA 3.1-405B model using the FP4 datatype. Measurements taken with an input length of 128 tokens/output length of 2048 tokens on an 8x GPU AMD Instinct MI355X platform. AMD results were compared to the published throughput results for the NVIDIA B200 HGX 8x GPU platform. Server manufacturers may vary configurations, yielding different results. Performance may vary based on the use of the latest drivers and optimizations. MI350-038
  2. 9xx5TCO-001B: This scenario contains many assumptions and estimates and, while based on AMD internal research and best approximations, should be considered an example for information purposes only, and not used as a basis for decision making over actual testing. The AMD Server & Greenhouse Gas Emissions TCO (total cost of ownership) Estimator Tool - version 1.12, compares the selected AMD EPYC™ and Intel® Xeon® CPU based server solutions required to deliver a TOTAL_PERFORMANCE of 39100 units of SPECrate2017_int_base performance as of October 10, 2024. This scenario compares a legacy 2P Intel Xeon 28 core Platinum_8280 based server with a score of 391 versus 2P EPYC 9965 (192C) powered server with an score of 3000 (https://www.spec.org/cpu2017/results/res2024q4/cpu2017-20240923-44837.pdf) along with a comparison upgrade to a 2P Intel Xeon Platinum 8592+ (64C) based server with a score of 1130 (https://spec.org/cpu2017/results/res2024q3/cpu2017-20240701-43948.pdf). Actual SPECrate®2017_int_base score for 2P EPYC 9965 will vary based on OEM publications. Environmental impact estimates made leveraging this data, using the Country / Region specific electricity factors from the 2024 International Country Specific Electricity Factors 10 – July  2024, and the United States Environmental Protection Agency 'Greenhouse Gas Equivalencies Calculator'.